11
Sep

Multi-pass, single-molecule nanopore reading of long protein strands

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07935-7

A technique for threading long protein strands through a nanopore by electrophoresis and back using a protein unfoldase motor, ClpX, enables single protein molecules to be analyzed multiple times with single-amino-acid sensitivity.