30
Oct

Polyclonality overcomes fitness barriers in Apc-driven tumorigenesis

Nature, Published online: 30 October 2024; doi:10.1038/s41586-024-08053-0

Multicolour lineage tracing and mutagenesis studies in a mouse model show that many intestinal tumours are polyclonal, with multiple clones exhibiting independent Apc mutations driven by differences in KRAS and MYC signalling.