30
Oct
Polyclonality overcomes fitness barriers in Apc-driven tumorigenesis
Nature, Published online: 30 October 2024; doi:10.1038/s41586-024-08053-0
Multicolour lineage tracing and mutagenesis studies in a mouse model show that many intestinal tumours are polyclonal, with multiple clones exhibiting independent Apc mutations driven by differences in KRAS and MYC signalling.
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