25
Sep

Transferrin receptor targeting chimeras for membrane protein degradation

Nature, Published online: 25 September 2024; doi:10.1038/s41586-024-07947-3

Transferrin receptor targeting chimeras have been developed that enable targeting of drug resistance in epidermal growth factor receptor-driven lung cancer and reversible control of human primary chimeric antigen receptor T cells, representing a promising new family of bifunctional antibodies for targeted cancer therapy.